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Greater LDL Cholesterol Reduction beside VYTORIN-TM- Compared to Lipitor Resulted contained with Greater Goal Attainment At Most Common Doses - Results from a foreign clinical suffering conduct in 1,902 patients with elevated cholesterol show that VYTORIN(TM) (ezetimibe/simvastatin) allot greater slimming down in LDL (”bad”) cholesterol across the dose ranges compare to Lipitor. At the maximum ordinarily previously own starting dose of these two therapy, VYTORIN 10/20 mg push less significant quantity LDL cholesterol by 51 percent compared with 36 percent in elevation of Lipitor 10 mg (p less than 0.001).

In a subgroup of high hazard patients (CHD or CHD risk equivalent), principal difference in LDL cholesterol reduction at these doses resulted in more patients achieve a objective of less than 100 mg/dL with VYTORIN by way of compared to Lipitor; clearly, 82 percent of high risk patients opposing VYTORIN 10/20 mg (n=106) achieve a cholesterol make self-conscious goal of less than 100 mg/dL as compared to special 47 percent for patients on Lipitor 10 mg (n=106, p less than 0.001). High risk patients in the sanctum with a goal of less than 100 mg/dL who be taking VYTORIN 10/20 mg have a baseline LDL cholesterol of 166 mg/dL as compared to patients taking Lipitor 10 mg who had a baseline of 169 mg/dL.

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Additional results from the study showed that VYTORIN 10/40 mg decreased LDL cholesterol by 59 percent compared to 48 percent for Lipitor 40 mg in the subgroup of high risk patients. These patients had a baseline LDL cholesterol values of 169 mg/dL and 175 mg/dL respectively (p less than 0.001). In a post-hoc analysis of these notes, significant differences in LDL cholesterol reductions, by any means doses compared, resulted in more high risk patients achieving LDL cholesterol level less than 70 mg/dL with VYTORIN as compared to Lipitor. In loyal, 57 percent of high risk patients taking VYTORIN 10/40 mg (n=112) achieved a LDL cholesterol goal of less than 70 mg/dL as compared with 23 percent of the patients (n=115) taking Lipitor 40 mg (p less than 0.001).

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